Atherosclerosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2016-12-09Clinical Trial Update: The Contribution of Endothelin to Vasomotor Function in Diseased Coronary Arteries [NA]
This completed trial investigated the contribution of endothelin to vasomotor function in diseased coronary arteries. The Brigham and Women'…
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CLINICAL_TRIALS trial_result · 2016-12-05Clinical Trial Update: Study to Determine the Effect of 14 Days Dosing With Darapladib (SB-480848) on Carotid Plague Composition in Patients With Planned Carotid Endarterectomy [Phase 2]
Phase 2 trial assessing 14 days of darapladib on carotid plaque composition in patients with atherosclerosis undergoing carotid endarterecto…
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CLINICAL_TRIALS trial_result · 2016-12-05Clinical Trial Update: A Study Investigating the Concentrations of Darapladib in Blood and the Safety of This Compound in Healthy Japanese Men [Phase 1]
This Phase 1 study assesses how Darapladib concentrates in the blood and evaluates safety in healthy Japanese men.
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CLINICAL_TRIALS trial_result · 2016-12-05Clinical Trial Update: A Study To Determine The Effect Of SB-480848 On Asthma [Phase 1]
A Phase 1 study by GlaxoSmithKline evaluating SB-480848 in asthma, with atherosclerosis listed as a condition, has completed.
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CLINICAL_TRIALS trial_result · 2016-12-01Clinical Trial Update: An Imaging Study in Patients With Atherosclerosis Taking Rilapladib or Placebo for 12 Weeks [Phase 2]
A Phase 2 imaging study comparing rilapladib versus placebo in patients with atherosclerosis over 12 weeks has completed.
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CLINICAL_TRIALS trial_result · 2016-11-30Clinical Trial Update: Determining the Relationship Between the Atherosclerosis and Periodontopathogenic Microorganisms [NA]
This clinical trial update reports on a completed study evaluating the relationship between atherosclerosis and periodontopathogenic microor…
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CLINICAL_TRIALS trial_result · 2016-11-16Clinical Trial Update: A Healthy Volunteer Pharmacokinetic Study of Single and Repeat Doses of SB-480848 [Phase 1]
A Phase 1 pharmacokinetic study of single and repeat doses of SB-480848 in healthy volunteers has completed.
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CLINICAL_TRIALS trial_result · 2016-11-04Clinical Trial Update: A Single Ascending Dose Study Investigating the Safety, Pharmacokinetics and Pharmacodynamics of RO6836191 in Healthy Male Volunteers. [Phase 1]
Phase 1 single ascending dose study evaluating safety, pharmacokinetics and pharmacodynamics of RO6836191 in healthy male volunteers has com…
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CLINICAL_TRIALS trial_result · 2016-11-04Clinical Trial Update: A Study With Darapladib to Collect Tolerability Information [Phase 1]
Phase 1 trial update for darapladib to collect tolerability data in patients with atherosclerosis; the study has completed.
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CLINICAL_TRIALS trial_result · 2016-11-04Clinical Trial Update: Latinos Understanding the Need for Adherence [NA]
A clinical trial update from San Diego State University indicates the study on adherence among Latino participants with cardiovascular risk …
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CLINICAL_TRIALS trial_result · 2016-11-03Clinical Trial Update: Phase I Study of SB-480848(Darapladib) -Repeat Dose Study in Healthy Japanese Male Subjects- [Phase 1]
Phase I repeat-dose study of SB-480848 (darapladib) in healthy Japanese male subjects has been completed.
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CLINICAL_TRIALS trial_result · 2016-11-02Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, and Activity of Intravenous MLDL1278A in Patients on Standard-of-Care Therapy for Stable Atherosclerotic Cardiovascular Disease (GLACIER) [Phase 2]
A Phase 2 trial evaluating the intravenous agent MLDL1278A in patients with stable atherosclerotic cardiovascular disease on standard therap…
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CLINICAL_TRIALS trial_result · 2016-11-02Clinical Trial Update: Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial [Phase 4]
This document reports the completion status of the JPAD Phase 4 trial evaluating aspirin for primary prevention of atherosclerosis in people…
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CLINICAL_TRIALS trial_result · 2016-10-28Clinical Trial Update: Study Of The Effects Of SB 480848 (Darapladib) On The Electrical Conduction Of The Heart [Phase 1]
Phase 1 trial evaluating the effects of Darapladib (SB-480848) on electrical conduction in patients with atherosclerosis. The study status i…
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CLINICAL_TRIALS trial_result · 2016-10-21Clinical Trial Update: Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy [Phase 4]
Phase 4 trial assessing whether sitagliptin improves endothelial function in adults with type 2 diabetes on metformin; results were posted i…
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CLINICAL_TRIALS trial_result · 2016-09-23Clinical Trial Update: 7 Year Follow-up Study of the DanRisk Population
This clinical trial update reports results from a 7-year follow-up of the DanRisk population focusing on cardiovascular disease and related …
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CLINICAL_TRIALS trial_result · 2016-09-19Clinical Trial Update: The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases
The CASABLANCA study (Catheter Sampled Blood Archive in Cardiovascular Diseases) has completed status in the clinical trials registry. It in…
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CLINICAL_TRIALS trial_result · 2016-09-16Clinical Trial Update: Use of in Vivo 3T MR to Characterize Carotid Plaque in Patients and Correlate MR Findings With Symptoms
A completed trial used 3T MRI to characterize carotid plaque in patients and explored how MRI findings relate to symptoms to improve underst…
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CLINICAL_TRIALS trial_result · 2016-09-08Clinical Trial Update: Correlation Between Estimated Glomerular Filtration Rate(eGFR) and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)
A completed Korea University study examines how estimated glomerular filtration rate (kidney function) relates to vascular inflammation meas…
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CLINICAL_TRIALS trial_result · 2016-08-08Clinical Trial Update: SB-480848 In Subjects With Coronary Heart Disease [Phase 2]
Phase 2 trial of SB-480848 in subjects with coronary heart disease has completed. No efficacy results are provided in the update.
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CLINICAL_TRIALS trial_result · 2016-08-08Clinical Trial Update: Insulin Resistance Atherosclerosis Study (IRAS)
Update on the Insulin Resistance Atherosclerosis Study (IRAS), a completed NHLBI-funded clinical trial examining relationships between insul…
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CLINICAL_TRIALS trial_result · 2016-07-29Clinical Trial Update: MRI Derived Organ & Tissue Mass Changes With Weight Loss - Ancillary to Look AHEAD
This document summarizes results from an ancillary Look AHEAD trial examining MRI-derived changes in organ and tissue mass with weight loss.…
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CLINICAL_TRIALS trial_result · 2016-07-29Clinical Trial Update: Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome
A completed clinical trial evaluated whether polycystic ovary syndrome increases the risk of coronary artery disease and other cardiovascula…
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CLINICAL_TRIALS trial_result · 2016-07-29Clinical Trial Update: Cardiac MR of Subclinical CVD: Impact of Age
This completed NHLBI trial evaluates cardiac MRI in subclinical cardiovascular disease. It investigates how age affects MRI findings.
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CLINICAL_TRIALS trial_result · 2016-07-29Clinical Trial Update: Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease Risk
A completed clinical trial explored whether differences in peripheral blood leukocyte gene expression can predict cardiovascular disease ris…