Apnea of Prematurity
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2024-09-19Clinical Trial Update: Confirmation of Tube Placement in Newborns [NA]
A clinical trial (NCT05229887) titled 'Confirmation of Tube Placement in Newborns' has been withdrawn. It involved Respiratory distress synd…
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CLINICAL_TRIALS trial_result · 2024-07-30Clinical Trial Update: CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure [NA]
A clinical trial comparing CPAP versus unsynchronized NIPPV at equal mean airway pressure in premature infants with respiratory distress syn…
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CLINICAL_TRIALS trial_result · 2024-07-08Clinical Trial Update: Effect of High Frequency Oscillatory Highflow Nasal Cannula on Desaturations and Bradycardia in Preterm Infants [NA]
A completed clinical trial evaluating the effect of a high-frequency oscillatory high-flow nasal cannula on desaturation and bradycardia in …
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CLINICAL_TRIALS trial_result · 2024-06-28Clinical Trial Update: Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial [Phase 3]
A Phase 3 trial (MoCHA) evaluating caffeine citrate for apnea of prematurity in moderately preterm infants was terminated; results have been…
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Baby-CINO: CaffeINe Treatment Optimisation in Premature Infants
An update on the Baby-CINO trial at the University of Oxford investigating caffeine treatment optimization for premature infants; the curren…
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CLINICAL_TRIALS research · 2024-05-06Clinical Trial Update: The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate [Phase 4]
A Phase 4 trial from Semmelweis University is evaluating whether an additional pre-extubational loading dose of caffeine citrate affects out…
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CLINICAL_TRIALS trial_result · 2024-04-04Clinical Trial Update: Doxapram Therapy in Preterm Infants (DOXA Trial) [Phase 3]
Phase 3 trial update for doxapram therapy in preterm infants with apnea of prematurity and respiratory insufficiency; currently recruiting.
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CLINICAL_TRIALS trial_result · 2023-10-18Clinical Trial Update: Target Weaning Oxygen to Determine Cafffeine Duration for AOP [Phase 4]
Phase 4 trial updating caffeine duration based on oxygen weaning in apnea of prematurity has completed.
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CLINICAL_TRIALS trial_result · 2021-08-03Clinical Trial Update: Early Caffeine in Preterm Neonates [Phase 4]
A Phase 4 clinical trial update on early caffeine use in preterm neonates for bronchopulmonary dysplasia and apnea of prematurity; current s…
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CLINICAL_TRIALS trial_result · 2020-03-17Clinical Trial Update: A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation [NA]
A completed clinical trial comparing methods for discontinuing nasal CPAP in premature infants under 30 weeks gestation; results posted in 2…
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FDA approval · 2020-03-02FDA Approved: CAFFEINE CITRATE — Supplemental Application (Hikma Pharmaceuticals USA Inc.)
FDA approved a supplemental application for caffeine citrate by Hikma Pharmaceuticals USA Inc., updating the product’s labeling. The documen…
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CLINICAL_TRIALS trial_result · 2020-02-07Clinical Trial Update: A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants [NA]
A completed clinical trial comparing non-invasive ventilation methods to prevent endotracheal intubation due to apnea in very low birth weig…
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FDA approval · 2019-12-16FDA Approved: CAFFEINE CITRATE — Original Application (Micro Labs Limited)
FDA approved caffeine citrate from Micro Labs Limited through its Original Application for use as a respiratory stimulant in appropriate pat…
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CLINICAL_TRIALS trial_result · 2018-03-22Clinical Trial Update: Caffeine for Apnea of Prematurity (CAP) [Phase 3]
A Phase 3 trial evaluating caffeine citrate for apnea of prematurity has completed.
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FDA approval · 2017-12-14FDA Approved: CAFFEINE CITRATE — Original Application (Armas Pharmaceuticals Inc.)
FDA approved the original application for caffeine citrate from Armas Pharmaceuticals Inc., a generic drug used to treat apnea of prematurit…
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CLINICAL_TRIALS trial_result · 2017-06-19Clinical Trial Update: Caffeine to Reduce Mechanical Ventilation in Preterm Infants [NA]
Terminated clinical trial evaluating caffeine citrate to reduce the need for mechanical ventilation in preterm infants; results were posted …
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: Non-invasive Intervention for Apnea of Prematurity [NA]
A completed UCLA-sponsored clinical trial tested a non-invasive intervention for apnea of prematurity and related hypoxia and bradycardia; r…
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CLINICAL_TRIALS trial_result · 2017-03-21Clinical Trial Update: Effect of Caffeine on Preterm Infants' Bone Mineral Content
A completed clinical trial evaluated the impact of caffeine citrate on bone mineral content in preterm infants. It also examined apnea of pr…
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CLINICAL_TRIALS trial_result · 2017-03-08Clinical Trial Update: Nasogastric Versus Orogastric Route of Feeding in Preterm (<32 Weeks) Neonates [NA]
A completed clinical trial comparing nasogastric versus orogastric feeding in preterm neonates (<32 weeks).
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CLINICAL_TRIALS trial_result · 2017-02-27Clinical Trial Update: Dosing Chart for Calculating the First Dose of Doxapram in Premature Infants [Phase 4]
Phase 4 trial update provides dosing chart guidance for calculating the first dose of doxapram in premature infants with apnea of prematurit…
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FDA approval · 2017-01-02FDA Approved: CAFFEINE CITRATE — Supplemental Application (Sagent Pharmaceuticals)
The FDA approved a supplemental application for caffeine citrate submitted by Sagent Pharmaceuticals. This action updates the product's labe…
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CLINICAL_TRIALS research · 2016-05-17Clinical Trial Update: Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support [NA]
This clinical trial compares automated oxygen adjustment with adaptive mechanical backup ventilation to automated oxygen adjustment alone in…
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CLINICAL_TRIALS research · 2016-04-19Clinical Trial Update: Influence of Oxygen Target Range on Intermittent Hypoxemia in Preterm Infants [NA]
A clinical trial update examining how the target range of supplemental oxygen influences intermittent hypoxemia in preterm infants.
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CLINICAL_TRIALS trial_result · 2016-02-24Clinical Trial Update: MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine [Phase 4]
Phase 4 clinical trial update examining MRI findings and neurodevelopment in preterm infants treated with high-dose caffeine for apnea of pr…
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CLINICAL_TRIALS research · 2015-11-02Clinical Trial Update: The Effect of Stimulating Substances on Brain Activity of Preterm Infants
This clinical trial update covers a study investigating the effect of stimulating substances on brain activity in preterm infants with apnea…