Anal Fissure
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2017-07-25Clinical Trial Update: Multi-Drug Analgesia vs. Standard Solution for Anal Surgery [Phase 4]
Phase 4 trial comparing multi-drug analgesia to a standard solution for anal surgery has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2017-07-17Clinical Trial Update: PK, PD and Safety Comparative Trial of Isosorbide Mononitrate Gel in Healthy Participants and With Anal Fissure [Phase 1]
A Phase 1 PK/PD and safety comparison trial of topical isosorbide mononitrate gel in healthy participants and in individuals with Anal fissu…
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CLINICAL_TRIALS trial_result · 2016-11-15Clinical Trial Update: Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery [Phase 4]
Phase 4 trial assessing the efficacy and safety of CLIFE1 Gel in benign anorectal surgery has completed. The study evaluated CLIFE1 Gel for …
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CLINICAL_TRIALS trial_result · 2016-11-03Clinical Trial Update: A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures [Phase 3]
A Phase 3 trial evaluated nitroglycerin ointment 0.4% (Cellegesic) for pain relief in chronic anal fissures; the study is completed and resu…
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CLINICAL_TRIALS trial_result · 2016-03-07Clinical Trial Update: Glyceryl Trinitrate Ointment vs Posterior Tibial Nerve Stimulation in the Treatment of Anal Fissure [Phase 3]
Phase 3 trial comparing glyceryl trinitrate ointment to posterior tibial nerve stimulation for anal fissure has completed; no results are pr…
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CLINICAL_TRIALS research · 2016-03-01Clinical Trial Update: Pediatrics Anal Fissures Treatment With Polyethylene Glycol [Phase 4]
A Phase 4 clinical trial is evaluating polyethylene glycol for pediatric anal fissures; current status is unknown.
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CLINICAL_TRIALS trial_result · 2015-12-11Clinical Trial Update: A Novel Method for Chronic Anal Fissure Treatment [NA]
The clinical trial investigating a novel method for treating chronic anal fissure has completed.
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CLINICAL_TRIALS trial_result · 2015-11-17Clinical Trial Update: An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing [Phase 1, Phase 2]
Open-label Phase 1/2 study evaluating the effect of a coated nifedipine suppository on anal fissure pain and healing; the trial has been ter…
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CLINICAL_TRIALS research · 2015-10-19Clinical Trial Update: Trial on Use of Coloshield in Transanal and Anal Surgery [NA]
Clinical trial update for Coloshield in transanal and anal surgery. The document lists conditions including anal fistula, rectal polyps, rec…
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CLINICAL_TRIALS withdrawal · 2015-05-04Clinical Trial Update: Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure [Phase 4]
A Phase 4 clinical trial evaluating the pharmacokinetics, safety, and exploratory efficacy of RECTIV in adolescents with chronic anal fissur…
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CLINICAL_TRIALS trial_result · 2015-03-24Clinical Trial Update: Transcutaneous Posterior Tibial Nerve Stimulation for Treatment of Chronic Anal Fissure [NA]
A clinical trial evaluating transcutaneous posterior tibial nerve stimulation for chronic anal fissure has completed. The study is sponsored…
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CLINICAL_TRIALS trial_result · 2015-03-20Clinical Trial Update: Ultrasound Guided Lateral Sphincterotomy: Long Term Results
Update on long-term results of ultrasound-guided lateral sphincterotomy for treating anal incontinence following chronic anal fissure.
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CLINICAL_TRIALS trial_result · 2014-07-01Clinical Trial Update: Diltiazem Hydrochloride Cream for Anal Fissure [Phase 3]
Phase 3 clinical trial update evaluating diltiazem hydrochloride cream for chronic anal fissure has completed with results posted.
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CLINICAL_TRIALS trial_result · 2014-01-23Clinical Trial Update: Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures [Phase 3]
Phase 3 clinical trial update assessing the efficacy and safety of diltiazem hydrochloride cream for treating anal fissures, with the study …
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CLINICAL_TRIALS research · 2013-08-21Clinical Trial Update: An Open-Label, Single- and Multi-Dose Pharmacokinetic (PK) Study of Oral Diltiazem and Topical Diltiazem Hydrochloride [Phase 1]
This is an open-label Phase 1 pharmacokinetic study of oral and topical diltiazem hydrochloride in adults with anal fissures, with the statu…
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CLINICAL_TRIALS trial_result · 2013-01-11Clinical Trial Update: Oligo-antigenic Diet in the Treatment of Chronic Anal Fissures. [NA]
A completed clinical trial evaluating an oligoantigenic diet for the treatment of chronic anal fissures, sponsored by the University of Pale…
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CLINICAL_TRIALS research · 2012-06-01Clinical Trial Update: Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine [NA]
Clinical trial update about measuring stress during anesthesia using the Pain Detector device in patients receiving atropine, with hemorrhoi…
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CLINICAL_TRIALS trial_result · 2011-12-29Clinical Trial Update: Conventional Lateral Internal Sphincterotomy, V-Y Anoplasty and Tailored Lateral Internal Sphincterotomy With V-YF in Treatment of Chronic Anal Fissure(CAF) [NA]
This clinical trial completed evaluation of three surgical approaches for chronic anal fissure: conventional lateral internal sphincterotomy…
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FDA approval · 2011-06-21FDA Approved: RECTIV — Original Application (Allergan, Inc.)
FDA approved RECTIV (nitroglycerin) ointment in its original application for the treatment of chronic anal fissure, developed by Allergan, I…
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CLINICAL_TRIALS trial_result · 2011-02-16Clinical Trial Update: An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects [Phase 1, Phase 2]
Completed open-label Phase 1/2 study evaluating the effect of a coated nifedipine suppository on anal fissure pain and healing.
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CLINICAL_TRIALS trial_result · 2010-05-28Clinical Trial Update: Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% Ointment for Chronic Anal Fissure [Phase 3]
Phase 3 trial comparing perianal versus endoanal application of 0.4% glyceryl trinitrate ointment for chronic anal fissure has completed.
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CLINICAL_TRIALS trial_result · 2010-03-30Clinical Trial Update: Comparison of Botulinum Toxin and Sphincterotomy in the Treatment of Chronic Anal Fissure
Clinical trial comparing botulinum toxin injections to sphincterotomy for chronic anal fissure has completed.
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CLINICAL_TRIALS research · 2009-12-24Clinical Trial Update: Diet and Lifestyle Intervention Study in Postpartum Women in China [Phase 2, Phase 3]
Phase 2/Phase 3 clinical trial in postpartum Chinese women examining the impact of diet and lifestyle interventions on postpartum conditions…
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CLINICAL_TRIALS research · 2009-09-21Clinical Trial Update: The Importance of Lateral Internal Sphincterotomy Incision: Parallel or Vertical
A clinical trial update evaluating whether parallel or vertical orientation of a lateral internal sphincterotomy incision affects outcomes i…
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CLINICAL_TRIALS trial_result · 2009-01-23Clinical Trial Update: Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure [Phase 4]
A Phase 4 trial comparing Botox injections into the internal anal sphincter versus isosorbide dinitrate ointment for anal fissure has comple…