Alzheimer Disease
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease (CLEAN-AD Registry)
CLEAN-AD Registry is a clinical trial update evaluating deep cervical lymphatic venous anastomosis as a treatment for Alzheimer's disease. T…
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CLINICAL_TRIALS trial_result · 2025-07-09Clinical Trial Update: Intergenerational Behavioral Intervention to Enhance Physical Activity in Older Adults at Risk for Alzheimer's Disease [NA]
This clinical trial update reports completion of an intergenerational behavioral intervention to increase physical activity in older adults …
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
This clinical trial is currently recruiting to investigate the role of white matter hyperintensities in individuals with amnestic mild cogni…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: Sleep Stimulation to Enhance Waste Clearance in the Brain [NA]
A clinical trial investigates sleep stimulation to enhance brain waste clearance. The study includes healthy individuals as well as those wi…
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CLINICAL_TRIALS trial_result · 2025-07-08Clinical Trial Update: Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects [Phase 1]
Phase 1 study of velusetrag in healthy elderly subjects assessing safety, pharmacokinetics and pharmacodynamics; Alzheimer's disease is list…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: hUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases [Phase 1]
Phase 1 trial update for hUC-MSC-sEV-001 nasal drops across several neurodegenerative diseases; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers [NA]
The clinical trial update shows that the University of Washington is recruiting for a study intended to promote goals-of-care discussions fo…
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: Activity of Cerebral Networks, Amyloid and Microglia in Aging and Alzheimer's Disease
A clinical trial examining cerebral networks, amyloid, and microglial biology in aging and Alzheimer's disease has completed, including part…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Amyloid-β Clearance Mechanisms in Alzheimer's Disease
This clinical trial is investigating amyloid-β clearance mechanisms in Alzheimer's disease and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-07-03Clinical Trial Update: Evaluating Rapamycin Treatment in Alzheimer's Disease Using Positron Emission Tomography [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating rapamycin for Alzheimer's disease using PET imaging has completed.
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: DECIDE: Dyads and Families [NA]
Clinical trial entry for the DECIDE: Dyads and Families study focusing on dementia and Alzheimer's disease, with recruitment currently open …
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease [Phase 2]
Phase 2 clinical trial investigating longitudinal imaging of microglial activation across clinical variants of Alzheimer disease, currently …
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias [NA]
A recruiting clinical trial at Centre Hospitalier Universitaire de Nice is studying mitochondrial function and metabolomic profiles in Alzhe…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: REXULTI Drug General Use-results Survey (Excessive Motor Activity or Physically/Verbally Aggressive Behavior Due to Rapid Changes in Mood, Irritability, and/or Outbursts Associated With Dementia Due to Alzheimer's Disease)
A study evaluating brexpiprazole (REXULTI) for behavioral symptoms in Alzheimer's-related dementia is currently recruiting.
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FDA approval · 2025-07-01FDA Approved: KISUNLA — Supplemental Application (Eli Lilly and Company)
FDA approved a supplemental application for Kisunla (donanemab-azbt) from Eli Lilly and Company.
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: Long-Term Follow-up of Gene Therapy for APOE4 Homozygote Alzheimer's Disease [Phase 1]
This document reports a long-term follow-up update from a Phase 1 gene therapy trial targeting APOE4 homozygosity in Alzheimer's disease, wi…
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Ozanimod in Patients With Alzheimer's Disease [Phase 2]
Phase 2 clinical trial update for Ozanimod in Alzheimer's disease. The study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Screening for Anti-amyloid Treatment Eligibility Using Digital Cognition and Blood-based Biomarkers
This trial update describes screening methods using digital cognition and blood-based biomarkers to determine eligibility for anti-amyloid t…
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Study of ASN51 in Adults With Early Alzheimer's Disease [Phase 2]
A Phase 2 study of ASN51 for adults with early Alzheimer's disease was terminated, and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: 7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD [NA]
This entry notes the completion of a clinical trial evaluating 7T MRI-guided light therapy in individuals with Mild Cognitive Impairment and…
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: Disclosing Dementia Risk Based on Plasma Phosphorylated Tau [NA]
A completed clinical trial evaluating whether plasma phosphorylated tau can disclose dementia risk in individuals with Alzheimer's disease o…
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CLINICAL_TRIALS research · 2025-06-29Clinical Trial Update: R21 Roche: 3-Way Tau Tracers in AD [Phase 1]
A Phase 1 clinical trial sponsored by Washington University and Roche is evaluating three tau tracer compounds for Alzheimer's disease; the …
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Brain Health in Midlife
A University of Kansas Medical Center-sponsored clinical trial focusing on brain health in midlife has completed. The study touches on gesta…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition [Phase 2]
Phase 2 clinical trial update from Vanderbilt University Medical Center examining cholinergic integrity in individuals with Down syndrome to…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Mindfulness to Enhance Cognitive Health in Latinx Older Adults [NA]
An ongoing Washington University School of Medicine trial is testing whether mindfulness can improve cognitive health in Latinx older adults…