Alpha-1 Antitrypsin Deficiency
📧 Sign up to get email alerts when something new happens for Alpha-1 Antitrypsin Deficiency.
Sign up freeTop drugs studied for this disease
-
CLINICAL_TRIALS trial_result · 2021-10-14Clinical Trial Update: GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study [Phase 3]
Phase 3 trial update on GLASSIA assessing safety, immunogenicity, and bronchoalveolar lavage in alpha-1 antitrypsin deficiency has completed…
-
CLINICAL_TRIALS trial_result · 2021-10-12Clinical Trial Update: Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency [Phase 2]
Phase 2 trial investigating carbamazepine for severe liver disease due to Alpha-1 antitrypsin deficiency was terminated; results posted late…
-
CLINICAL_TRIALS trial_result · 2021-05-05Clinical Trial Update: Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency [Phase 1, Phase 2]
Summary of a safety study evaluating an aerosolized recombinant alpha1-antitrypsin in individuals with alpha1-antitrypsin deficiency (Phase …
-
CLINICAL_TRIALS trial_result · 2021-05-05Clinical Trial Update: Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency [Phase 1, Phase 2]
A clinical trial evaluating aerosolized recombinant alpha-1 antitrypsin in subjects with alpha-1 antitrypsin deficiency has completed Phase …
-
CLINICAL_TRIALS trial_result · 2021-02-18Clinical Trial Update: Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin Deficiency [Phase 1, Phase 2]
A completed Phase 1/2 trial evaluating safety and pharmacokinetics of Alpha-1 MP (modified process human alpha1-proteinase inhibitor) in ind…
- Want full summaries, importance scores, and drug timelines? Upgrade to Plus or Pro.
-
CLINICAL_TRIALS trial_result · 2021-02-17Clinical Trial Update: Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency [Phase 2]
Phase 2 clinical trial update investigating targeting pulmonary perfusion in alpha-1 antitrypsin deficiency with results posted.
-
CLINICAL_TRIALS trial_result · 2020-04-21Clinical Trial Update: Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency [Phase 2]
Phase 2 trial evaluating the efficacy and safety of an inhaled HA solution for hereditary emphysema due to alpha-1 antitrypsin deficiency ha…
-
CLINICAL_TRIALS trial_result · 2020-01-18Clinical Trial Update: Phase II, Safety and Efficacy Study of Kamada-alpha-1-antitrypsin (AAT) for Inhalation" [Phase 2]
Phase II trial assessing inhaled Kamada-alpha-1-antitrypsin for Alpha-1 Antitrypsin Deficiency completed with posted results.
-
CLINICAL_TRIALS trial_result · 2019-10-08Clinical Trial Update: Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency [Phase 3]
Phase 3 trial update for ARALAST NP and GLASSIA in alpha-1 antitrypsin deficiency (A1PI) has terminated; results posted.
-
CLINICAL_TRIALS trial_result · 2019-07-22Clinical Trial Update: Alpha-1 Carrier Genomics Study
A completed clinical trial study on Alpha-1 Antitrypsin Deficiency and Emphysema with results posted in 2019.
-
CLINICAL_TRIALS trial_result · 2019-05-08Clinical Trial Update: Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation. [Phase 2]
A Phase 2 clinical trial investigated the effects of a double dose of alpha-1 antitrypsin augmentation therapy on lung inflammation in patie…
-
CLINICAL_TRIALS trial_result · 2018-08-03Clinical Trial Update: A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD) [Phase 1]
Phase 1 study evaluating ARC-AAT in healthy volunteers and patients with Alpha-1 Antitrypsin Deficiency (AATD) was terminated; results were …
-
CLINICAL_TRIALS trial_result · 2018-07-16Clinical Trial Update: The Impact of Delayed Diagnosis of Alpha-1 Antitrypsin Deficiency
A completed clinical trial update examining the impact of delayed diagnosis of Alpha-1 Antitrypsin Deficiency on patient outcomes. The study…
-
CLINICAL_TRIALS trial_result · 2018-07-13Clinical Trial Update: Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability [NA]
Phase 2 trial evaluating ex-vivo lung perfusion and ventilation to assess transplant suitability, sponsored by the University of North Carol…
-
CLINICAL_TRIALS trial_result · 2018-04-20Clinical Trial Update: Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability [NA]
This completed clinical trial evaluated ex-vivo perfusion and ventilation of donor lungs recovered from non-heart-beating donors to assess t…
-
CLINICAL_TRIALS trial_result · 2017-05-04Clinical Trial Update: Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant [Phase 3]
Phase 3 randomized trial comparing Simulect (basiliximab) plus standard immunosuppression to standard immunosuppression alone for prevention…
-
CLINICAL_TRIALS trial_result · 2017-03-13Clinical Trial Update: A Study to Assess Safety and PK of Liquid Alpha₁-Proteinase Inhibitor (Human) in Treating Alpha₁-Antitrypsin Deficiency [Phase 2, Phase 3]
This clinical trial update reports safety and pharmacokinetic results from a Phase 2/3 study of liquid human alpha-1 proteinase inhibitor in…
-
CLINICAL_TRIALS trial_result · 2016-12-15Clinical Trial Update: Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency [Phase 1]
Phase 1 clinical trial results posted for an experimental gene transfer procedure aimed at treating Alpha-1 antitrypsin deficiency.
-
CLINICAL_TRIALS trial_result · 2016-07-12Clinical Trial Update: Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency. [Phase 4]
This is a Phase 4 extension study of intravenous Zemaira in subjects with emphysema due to alpha-1 antitrypsin deficiency; results from the …
-
CLINICAL_TRIALS trial_result · 2016-03-25Clinical Trial Update: Alpha1-antitrypsin Deficiency Registry
A completed NHLBI-sponsored clinical trial registry update for Alpha-1 antitrypsin deficiency and related lung diseases such as emphysema an…
-
CLINICAL_TRIALS trial_result · 2015-01-19Clinical Trial Update: Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency [Phase 4]
Phase 4 clinical trial update reporting Zemaira (alpha-1 proteinase inhibitor) results in subjects with emphysema due to alpha-1 antitrypsin…
-
CLINICAL_TRIALS trial_result · 2014-09-09Clinical Trial Update: Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults [Phase 3]
Phase 3 trial comparing pharmacokinetics, safety, and tolerability of Alpha-1 MP versus Prolastin in adults with Alpha-1 antitrypsin deficie…
-
CLINICAL_TRIALS trial_result · 2014-08-21Clinical Trial Update: Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE) [Phase 2]
EXACTLE is a Phase 2 trial evaluating Alpha-1 antitrypsin therapy for emphysema in patients with Alpha-1 antitrypsin deficiency. Results wer…
-
CLINICAL_TRIALS trial_result · 2014-08-19Clinical Trial Update: The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency [Phase 3]
Phase 3 trial evaluating the safety and tolerability of Alpha-1 Modified Process (MP) in individuals with Alpha-1-antitrypsin deficiency; re…
-
CLINICAL_TRIALS trial_result · 2014-05-29Clinical Trial Update: GLASSIA Infusion Rate Study [Phase 4]
Phase 4 trial update on GLASSIA infusion rate study; completed with results posted in 2014.